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Notably, tirzepatide can reduce the effectiveness of oral contraceptives during initiation and dose increases

That is a substantial rate for a side effect that neither semaglutide nor tirzepatide produces at any meaningful frequency

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Subsequently, the undiluted samples were analyzed on an HPLC system (1200 series, Agilent Technologies Deutschland GmbH, Bblingen, Germany) with an organic acid resin column (300 mm 8 mm) and the corresponding pre-column (40 mm 8 mm) (Chromatographie-Service GmbH, Langerwehe, Germany) heated to 60C